Los Algodones, Baja California, is a small Mexican town located in the northeast corner of the municipality of Mexicali, about 16 km (10 miles) west of Yuma, Arizona, USA). Located near the borders of both southeastern California and southwestern Arizona, Los Algodones has become a popular tourist attraction in recent years due in part to low-cost shopping and restaurants, as well as medical care under and prescription drug costs.

The warm, dry climate of the area attracts a number of elderly tourists from across the United States and Canada that are set during the winter in the nearby towns of Yuma, Arizona, and Winterhaven, California. Organized trips daily from the Coachella Valley are popular with older people too. On the U.S. side, Los Algodones is most easily reached by Interstate 8 and south a short distance (3.33 km / 2.07 miles) along the Road to State Route 186/Andrade the international border at Andrade, California.

in Andrade, visitors can choose to park their vehicles for a small fee and cross the border or to drive across. The popularity of both inexpensive prescriptions and medical care serving Canadian and U.S. citizens have caused a high virtual explosion of pharmacies and dental offices that largely displaced a large number of outdoor shops and restaurants immediately across the border and have shifted the focus of effective city tourism to medicine. However, a number of shops and restaurants stay and Los Algodones capitalizes on the tourist trade with frequent festivals throughout the year, especially during the Christmas season.